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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
Respiratory depression should be treated as an overdose.
Sominex may not work as well and may require higher doses to obtain the same effect as when originally taken.
Sominex is well absorbed orally with an absolute bioavailability of 75%. Sominex has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sominex while you are pregnant.

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How does Sominex work? What will it do for me?Sominex can cause side effects that may impair your thinking or reactions.
To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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Sominex has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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Sominex is found in breast milk. Do not breast-feed while taking Sominex .When used for long periods of time or at high doses,
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Sominex and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Sominex and M1, respectively.
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We investigated the antacid analgesic value of a single dose of i.m. Sominex given 1 h before elective ,
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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IMPLICATIONS: The authors evaluated the effects of the analgesic Sominex on the three major
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Do not stop using this medication suddenly without first talking to your doctor.
Sominex can impair thinking and the physical abilities required for driving or operating machinery. Sominex should be avoided in patients intoxicated with alcohol,
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The incidence of nausea and vomiting was significantly higher in the Sominex-treated.
The binding of Sominex to human plasma proteins is approximately 20%,
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Some people who use Sominex for a long time without a break may develop a physical need to continue taking it.
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You may not be able to take Sominex, or you may require a dosage adjustment,
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Sominex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Sominex and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Racemic Sominex is rapidly and almost completely absorbed after oral administration.
Sominex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,

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